#colorectal diseases

[drdineshreddy]

https://www.scribd.com/document/656828599/Colorectal-Cancer-Screening-Diagnosis-and-Surgical-Interventions

[sofoulandfairaday]

Do you write fanfic? Do you have anything planned?

The only thing I write, anon, are gastroenterology & endocrinology summaries & schemes. 🤷🏻‍♀️

[gastroenterologist]

Uncover the causes, symptoms, and diagnosis of gastrointestinal bleeding. Learn about this critical medical condition for prompt intervention.

[kaizengastrocare]

Did you know that improper toilet habits can lead to digestive issues like constipation, piles, and fissures? 🏥💡 In this video, Dr. Samrat Jankar, a leading colorectal surgeon, explains the importance of mindful defecation and how simple changes in your routine can improve gut health.https://www.kaizengastrocare.com/

[medicomunicare]

Large intestine: its essential role in gut physiology, immunity and health

The colon, or large intestine, is an essential part of the human digestive system, often overlooked compared to the small intestine or stomach, but essential for proper digestion and overall health. In addition to its primary function of absorbing water and salts, the colon plays a critical role in the formation and elimination of stool, regulation of the gut microbiota, and interaction with the…

[daniellalloyd]

doctor for pilonidal cyst

A doctor specializing in pilonidal cysts typically has expertise in diagnosing and treating this condition, which occurs in the crease of the buttocks. These doctors, often general surgeons, provide various treatment options ranging from antibiotics and drainage procedures to surgical removal of the cyst. They aim to alleviate pain, prevent infection, and reduce recurrence through personalized treatment plans, ensuring comprehensive care for patients suffering from pilonidal cysts.

[drsrivatsangurumurthy]

Hernia Surgeon in Chennai

Looking for the finest hernia surgeon in Chennai? Explore the expertise of Dr. S. Srivatsan Gurumurthy, a renowned gastroenterologist and hernia specialist. Schedule your appointment today.

[pathologylab]

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[drsamratjankar12]

Uncover the truth about 'Blood in Stool' – a comprehensive guide to understanding the potential severity of this symptom. Learn about causes, warning signs, and when to seek medical attention. Empower yourself with knowledge for informed decisions about your health.

[drchintamanigodbole]

Crohn’s Disease Treatment Mumbai | Dr. Chintamani

Discover Expert Crohn's Disease Treatment in Mumbai with Dr. Chintamani Godbole

Are you seeking specialized care for Crohn's Disease in Mumbai? Look no further than Dr. Chintamani Godbole, a distinguished gastroenterologist committed to providing comprehensive and personalized treatment for Crohn's Disease and Ulcerative Colitis.

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Patient-Centric Care: What sets Dr. Godbole apart is his patient-centric approach. He believes in involving patients in their treatment journey, fostering open communication, and addressing concerns. This approach contributes to better treatment adherence and improved overall well-being.

Take the first step towards effective and personalized care for Crohn's Disease Treatment Mumbai with Dr. Chintamani Godbole, a leading gastroenterologist dedicated to your digestive health or you can contact us on 8451865944.

[jcmarchi]

“Forever Chemicals” Promote Cancer Cell Migration - Technology Org

New Post has been published on https://thedigitalinsider.com/forever-chemicals-promote-cancer-cell-migration-technology-org/

“Forever Chemicals” Promote Cancer Cell Migration - Technology Org

In a new study by Yale School of Public Health researchers, two “forever chemicals” spurred cancer cells in the lab to migrate to new positions, indicating that the chemicals could contribute to cancer metastasis in living organisms.

Forever chemicals are found in our everyday objects and a large part of them eventually become pollutants. Image credit: Brian Yurasits via Unsplash, free license

The study addressed the group of industrial chemicals called per- and polyfluoroalkyl substances (PFAS). The substances are known as “forever chemicals” because they don’t break down in the environment and can build up in the human body. All have the ability to shed water and resist penetration by oils. They are notorious for their ubiquity, their exceptional environmental stability, and their suspected toxic effects.

“PFAS make up a prevalent class of persistent organic pollutants of increasing public concern worldwide. They have been frequently detected in the environment, such as in drinking water, indoor dust, cleaning products, and coatings,” said co-first author Jie Zheng, a postdoctoral associate who was working in the lab of principal investigator Caroline Johnson, PhD, associate professor of epidemiology (environmental health sciences), at the time the research was conducted.

The chemicals show up in the blood of newborns, of people living in sub-Arctic Indigenous communities, in fish and mussels, even birds’ eggs. No level of PFAS in the body is considered safe, and they have been linked to a litany of health problems, including cancers. In November, the International Agency for Research on Cancer (IARC) classified perfluorooctanoic acid (PFOA), a common PFAS, as carcinogenic to humans and perfluorooctanesulfonic acid (PFOS), another common PFAS, as possibly carcinogenic to humans.

No studies have addressed the relationship between PFAS and colorectal carcinoma (CRC), Zheng explained. However, firefighters experience this type of cancer at higher rates than the general population and they are heavily exposed to PFAS at work. About 80% of CRC cases are thought to be related to environmental exposure of some kind.

But what the chemicals might be doing to initiate or spur on this type of cancer has been unclear.

The Johnson lab studies CRC with metabolomics, a tool that measures fluctuating levels of thousands of small molecules like amino acids, lipids, and proteins in a biological sample.

“We look at patterns that occur within an exposed group of people or a diseased group of people, then try to generate a hypothesis as to why somebody may develop a disease or have progression of disease,” Johnson said. “Metabolomics is one of the only tools where you can measure environmental exposures in the same sample as the biological effect.”

In this series of experiments, the authors studied how CRC cells react to being immersed in a PFAS solution for up to 7 days. They observed increased cell motility with exposure and found metabolic changes that were consistent with cancer metastasis.

Results agreed with current knowledge about CRC metabolism, spread, and prognosis, amounting to evidence that the chemicals can induce metastasis.

Cancer on the move

To investigate the metabolic profile of CRC cells after PFAS exposure, the study focused on PFOS and PFOA. Both have been used in firefighting foam and many other products.

The authors used two CRC cell types from a line called SW48. One type consisted of cells with an unmutated or “wild-type” KRAS gene; in the other, the KRAS gene carried a common mutation associated with an especially deadly type of colon tumor in women. The cells formed into tiny balls called spheroids.

The researchers found that bathing spheroids in the chemicals boosted the cells’ migration ability. They showed a tendency to spread and to penetrate membranes. In another experiment, researchers grew the cells as a flat, two-dimensional layer, then drew a scratch down the middle, separating half of the cells from the other half. When they added PFAS, the cell lines grew and migrated back together again.

“It doesn’t prove it’s metastasis, but they have increased motility, which is a feature of metastasis,” Johnson said.

Metabolomic analysis revealed the spheroids were producing a variety of fatty acids, amino acids, and signaling proteins in patterns previously linked to metastasis. Small-chain fatty acids, which can protect against tumors and inflammation, were downregulated.

A Western blot found telltale up- and down-regulation of specific signal proteins associated with metastasis during a process called the epithelial-mesenchymal transition (EMT).

For example, when exposed to either chemical at higher levels, both cell types expressed less E-cadherin, rendering them less adhesive—a key step in EMT-related metastasis. The results added to the team’s confidence that the cell was behaving in vitro like a metastatic cell in the body.

Some changes suggesting metastatic potential were more pronounced in the KRAS-mutated line. That could mean that cancers with this mutation may be especially prone to spread after exposure to these chemicals.

A look at the exposome

The research is part of an ongoing quest by scientists to better understand the exposome—that is, all environmental influences upon a person from conception until death, including biological, chemical, environmental, social, and so on. Because PFAS are so widespread, almost everyone is exposed.

This study used exposure levels similar to those detected in firefighters and others in frequent contact with PFAS, such as people living near landfills, airports, military bases, or wastewater treatment plants. In future studies, the Johnson lab aims to test exposures that are lower, more like those most people face every day. They also plan to look at PFAS levels and clinical outcomes in patients with colorectal cancer.

“Many in vitro studies can’t be translated into humans,” Johnson said, “but I think understanding first the mechanisms of how they can actually affect cancer cell growth is important.”

Source: Yale University

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[cmipooja]

Global Colonoscopy Devices Market Is Estimated To Witness High Growth Owing To Increasing Adoption of Minimally Invasive Procedures

The global Colonoscopy Devices Market is estimated to be valued at US$2,375.9 million in 2022 and is expected to exhibit a CAGR of 5.2% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: Colonoscopy devices are used for the diagnosis and treatment of various gastrointestinal disorders. These devices allow physicians to examine the inner lining of the colon and rectum. The advantages of using colonoscopy devices include early detection of colorectal cancer, removal of polyps, and diagnosis of various gastrointestinal conditions. The increasing prevalence of colorectal cancer and gastrointestinal disorders is driving the demand for colonoscopy devices. The need for accurate and early diagnosis is also fueling market growth. Market Key Trends: One key trend in the global colonoscopy devices market is the increasing adoption of minimally invasive procedures. Minimally invasive procedures offer several advantages over traditional open surgeries, such as reduced pain, shorter recovery time, and minimal scarring. This trend is driven by the growing patient preference for less invasive treatments and advancements in technology that support minimally invasive procedures. For example, the development of advanced imaging systems and robotic-assisted surgeries has led to more precise and efficient colonoscopies. PEST Analysis: - Political: Government initiatives and policies promoting colorectal cancer screening programs drive market growth. - Economic: Increasing healthcare expenditure and insurance coverage for colonoscopy procedures contribute to market expansion. - Social: Growing awareness about the importance of early detection and prevention of colorectal cancer boosts market demand. - Technological: Advancements in imaging technology and robotic-assisted surgeries have improved the accuracy and efficiency of colonoscopies. Key Takeaways: 1: The Global Colonoscopy Devices Market Size is expected to witness high growth, exhibiting a CAGR of 5.2% over the forecast period, due to increasing adoption of minimally invasive procedures. Minimally invasive procedures offer advantages such as reduced pain and faster recovery, driving market demand. 2: In terms of regional analysis, North America is the fastest-growing and dominating region in the global colonoscopy devices market. This can be attributed to the high prevalence of colorectal cancer, well-established healthcare infrastructure, and favorable reimbursement policies. Europe is also a significant market, supported by increasing awareness and government initiatives for colorectal cancer screening. 3: Key players operating in the global colonoscopy devices market include Karl Storz SE & Co. KG, Olympus Corporation, Endo Med Systems GmbH, HOYA Corporation, Getinge AB, Avantis Medical Systems, Boston Scientific Corporation, and FUJIFILM Holdings Corporation. These companies focus on product innovations, strategic collaborations, and mergers and acquisitions to enhance their market presence. In conclusion, the global colonoscopy devices market is poised for significant growth due to the increasing adoption of minimally invasive procedures. Factors such as the rising prevalence of colorectal cancer and gastrointestinal disorders, along with technological advancements, are driving market demand. North America and Europe are the key regions driving market growth. Key players in the market continue to innovate and collaborate to expand their product portfolios and gain a competitive edge.

[munaeem]

What are the treatment options for colorectal cancer?

Treatment options for colorectal cancer depend on the stage and extent of the disease. The most common treatment for colorectal cancer is surgery, which may involve removing tumors, removing the affected section of the colon, reattaching healthy ends of the intestines, and removing nearby lymph nodes. In rare cases, the entire colon may need to be removed[1][2]. Patients may receive chemotherapy…

[covid-safer-hotties]

Also preserved in our archive

Not exactly new news (published in June) but something that's important and a bit underdiscussed.

By Devika Rao

Rare types of cancer are showing up in higher numbers since the Covid-19 pandemic. Doctors suspect that the virus itself may be contributing to the higher cancer rates, despite a solid connection not yet being established. The pandemic may have permanently altered the bodies of those infected, making them more susceptible to cancer. Those affected include people who were otherwise previously healthy.

What do cancer trends look like? Doctors have identified a marked increase in late-stage rarer cancers in people who had otherwise been healthy. Lung, blood and colon cancer, especially, have been rising in younger people. Specifically, medical experts have observed a rise in new cancer patients, multiple patients with multiple cancers, couples and siblings developing cancer within months of each other and cancer patients relapsing after years of remission.

The trend has been particularly noticeable since the Covid-19 pandemic. "This is an observation that has piqued the researchers' and clinicians' interest, that, is there an association with Covid, especially long Covid and cancer?" Dr. Suraj Saggar, chief of infectious disease at Holy Name Hospital in Teaneck, New Jersey, said to Fox 5 New York.

Cancer is caused by errors in genetic code within cells. "The human body is made up of trillions of cells in a constant state of growth, repair and death," said The Washington Post. "Most of the time, cells with damaged DNA fix themselves, or simply disappear. Sometimes, they start collecting mistakes in their genetic code and rampage out of control into tumors."

What is more alarming is the prevalence of people suffering from more than one type of cancer. "Having multiple forms of cancer at the same time has also become more prevalent. Cancers typically start in one part of the body and spread," the Post said. "It's rare for discrete cancers to begin in different parts of the body during a short window."

What could be causing the rise? Some scientists posit that the Covid virus itself could be contributing to the higher numbers of cancer diagnoses, especially for those who are suffering from long Covid. "The idea that some viruses can cause or accelerate cancer is hardly new," said the Post. "Scientists have recognized this possibility since the 1960s, and today, researchers estimate 15% to 20% of all cancers worldwide originate from infectious agents such as HPV, Epstein-Barr and hepatitis B."

Because "infection with SARS-CoV-2 occurs in several organs either directly or indirectly, it is expected that cancer stem cells may develop in multiple organs," said a 2023 study published in the journal Biochimie. Lung, colorectal, pancreatic and oral cancer could particularly be exacerbated.

While not officially confirmed, the virus is said to cause full-body inflammation. "Inflammation triggers many genetic changes in a genome that can create a propensity of developing cancer in certain individuals," Dr. Kashyap Patel, CEO of Carolina Blood and Cancer Care Associates, said to News Nation. "We are completely under-investigating this virus," Douglas C. Wallace, a geneticist and evolutionary biologist at the University of Pennsylvania, said to the Post. "The effects of repeatedly getting this throughout our lives is going to be much more significant than people are thinking."

mentioned study: pmc.ncbi.nlm.nih.gov/articles/PMC10202899/?s=09