#colorectal diseases

[drdineshreddy]

https://www.scribd.com/document/656828599/Colorectal-Cancer-Screening-Diagnosis-and-Surgical-Interventions

[sofoulandfairaday]

Do you write fanfic? Do you have anything planned?

The only thing I write, anon, are gastroenterology & endocrinology summaries & schemes. 🤷🏻‍♀️

[gastroenterologist]

Uncover the causes, symptoms, and diagnosis of gastrointestinal bleeding. Learn about this critical medical condition for prompt intervention.

[medicomunicare]

Large intestine: its essential role in gut physiology, immunity and health

The colon, or large intestine, is an essential part of the human digestive system, often overlooked compared to the small intestine or stomach, but essential for proper digestion and overall health. In addition to its primary function of absorbing water and salts, the colon plays a critical role in the formation and elimination of stool, regulation of the gut microbiota, and interaction with the…

[daniellalloyd]

doctor for pilonidal cyst

A doctor specializing in pilonidal cysts typically has expertise in diagnosing and treating this condition, which occurs in the crease of the buttocks. These doctors, often general surgeons, provide various treatment options ranging from antibiotics and drainage procedures to surgical removal of the cyst. They aim to alleviate pain, prevent infection, and reduce recurrence through personalized treatment plans, ensuring comprehensive care for patients suffering from pilonidal cysts.

[drsrivatsangurumurthy]

Hernia Surgeon in Chennai

Looking for the finest hernia surgeon in Chennai? Explore the expertise of Dr. S. Srivatsan Gurumurthy, a renowned gastroenterologist and hernia specialist. Schedule your appointment today.

[pathologylab]

In the realm of #personalized medicine, #G2M offers Liquid Biopsy NGS #Panels, which stand out as revolutionary tools, offering unprecedented levels of sensitivity at a fraction of the traditional cost. These panels represent a cutting-edge approach to detecting and monitoring various diseases, including #colorectal, breast, and lung #cancer, with remarkable precision and efficiency.

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To know more about these NGS Panels, contact us at social@genes2me.com or call us +91-8800821778.

#genes2me #lungcancer #disease #liquidbiopsy #breastcancer #lungcancer #colorectalcancer #ctdna #dna #dnasequencing #madeinindia #manufacturing #nextgenerationsequencing #nextgeneration #india

[drsamratjankar12]

Uncover the truth about 'Blood in Stool' – a comprehensive guide to understanding the potential severity of this symptom. Learn about causes, warning signs, and when to seek medical attention. Empower yourself with knowledge for informed decisions about your health.

[drchintamanigodbole]

Crohn’s Disease Treatment Mumbai | Dr. Chintamani

Discover Expert Crohn's Disease Treatment in Mumbai with Dr. Chintamani Godbole

Are you seeking specialized care for Crohn's Disease in Mumbai? Look no further than Dr. Chintamani Godbole, a distinguished gastroenterologist committed to providing comprehensive and personalized treatment for Crohn's Disease and Ulcerative Colitis.

Understanding Crohn's Disease: Crohn's Disease is a chronic inflammatory bowel condition that can affect any part of the digestive tract. With its unpredictable nature, seeking expert medical attention is crucial for effective management.

Expertise in Gastrointestinal Disorders: Dr. Chintamani Godbole is renowned for his expertise in treating gastrointestinal disorders, including Crohn's Disease and Ulcerative Colitis. His approach involves a thorough understanding of each patient's unique condition, allowing for personalized treatment plans.

Patient-Centric Care: What sets Dr. Godbole apart is his patient-centric approach. He believes in involving patients in their treatment journey, fostering open communication, and addressing concerns. This approach contributes to better treatment adherence and improved overall well-being.

Take the first step towards effective and personalized care for Crohn's Disease Treatment Mumbai with Dr. Chintamani Godbole, a leading gastroenterologist dedicated to your digestive health or you can contact us on 8451865944.

[jcmarchi]

“Forever Chemicals” Promote Cancer Cell Migration - Technology Org

New Post has been published on https://thedigitalinsider.com/forever-chemicals-promote-cancer-cell-migration-technology-org/

“Forever Chemicals” Promote Cancer Cell Migration - Technology Org

In a new study by Yale School of Public Health researchers, two “forever chemicals” spurred cancer cells in the lab to migrate to new positions, indicating that the chemicals could contribute to cancer metastasis in living organisms.

Forever chemicals are found in our everyday objects and a large part of them eventually become pollutants. Image credit: Brian Yurasits via Unsplash, free license

The study addressed the group of industrial chemicals called per- and polyfluoroalkyl substances (PFAS). The substances are known as “forever chemicals” because they don’t break down in the environment and can build up in the human body. All have the ability to shed water and resist penetration by oils. They are notorious for their ubiquity, their exceptional environmental stability, and their suspected toxic effects.

“PFAS make up a prevalent class of persistent organic pollutants of increasing public concern worldwide. They have been frequently detected in the environment, such as in drinking water, indoor dust, cleaning products, and coatings,” said co-first author Jie Zheng, a postdoctoral associate who was working in the lab of principal investigator Caroline Johnson, PhD, associate professor of epidemiology (environmental health sciences), at the time the research was conducted.

The chemicals show up in the blood of newborns, of people living in sub-Arctic Indigenous communities, in fish and mussels, even birds’ eggs. No level of PFAS in the body is considered safe, and they have been linked to a litany of health problems, including cancers. In November, the International Agency for Research on Cancer (IARC) classified perfluorooctanoic acid (PFOA), a common PFAS, as carcinogenic to humans and perfluorooctanesulfonic acid (PFOS), another common PFAS, as possibly carcinogenic to humans.

No studies have addressed the relationship between PFAS and colorectal carcinoma (CRC), Zheng explained. However, firefighters experience this type of cancer at higher rates than the general population and they are heavily exposed to PFAS at work. About 80% of CRC cases are thought to be related to environmental exposure of some kind.

But what the chemicals might be doing to initiate or spur on this type of cancer has been unclear.

The Johnson lab studies CRC with metabolomics, a tool that measures fluctuating levels of thousands of small molecules like amino acids, lipids, and proteins in a biological sample.

“We look at patterns that occur within an exposed group of people or a diseased group of people, then try to generate a hypothesis as to why somebody may develop a disease or have progression of disease,” Johnson said. “Metabolomics is one of the only tools where you can measure environmental exposures in the same sample as the biological effect.”

In this series of experiments, the authors studied how CRC cells react to being immersed in a PFAS solution for up to 7 days. They observed increased cell motility with exposure and found metabolic changes that were consistent with cancer metastasis.

Results agreed with current knowledge about CRC metabolism, spread, and prognosis, amounting to evidence that the chemicals can induce metastasis.

Cancer on the move

To investigate the metabolic profile of CRC cells after PFAS exposure, the study focused on PFOS and PFOA. Both have been used in firefighting foam and many other products.

The authors used two CRC cell types from a line called SW48. One type consisted of cells with an unmutated or “wild-type” KRAS gene; in the other, the KRAS gene carried a common mutation associated with an especially deadly type of colon tumor in women. The cells formed into tiny balls called spheroids.

The researchers found that bathing spheroids in the chemicals boosted the cells’ migration ability. They showed a tendency to spread and to penetrate membranes. In another experiment, researchers grew the cells as a flat, two-dimensional layer, then drew a scratch down the middle, separating half of the cells from the other half. When they added PFAS, the cell lines grew and migrated back together again.

“It doesn’t prove it’s metastasis, but they have increased motility, which is a feature of metastasis,” Johnson said.

Metabolomic analysis revealed the spheroids were producing a variety of fatty acids, amino acids, and signaling proteins in patterns previously linked to metastasis. Small-chain fatty acids, which can protect against tumors and inflammation, were downregulated.

A Western blot found telltale up- and down-regulation of specific signal proteins associated with metastasis during a process called the epithelial-mesenchymal transition (EMT).

For example, when exposed to either chemical at higher levels, both cell types expressed less E-cadherin, rendering them less adhesive—a key step in EMT-related metastasis. The results added to the team’s confidence that the cell was behaving in vitro like a metastatic cell in the body.

Some changes suggesting metastatic potential were more pronounced in the KRAS-mutated line. That could mean that cancers with this mutation may be especially prone to spread after exposure to these chemicals.

A look at the exposome

The research is part of an ongoing quest by scientists to better understand the exposome—that is, all environmental influences upon a person from conception until death, including biological, chemical, environmental, social, and so on. Because PFAS are so widespread, almost everyone is exposed.

This study used exposure levels similar to those detected in firefighters and others in frequent contact with PFAS, such as people living near landfills, airports, military bases, or wastewater treatment plants. In future studies, the Johnson lab aims to test exposures that are lower, more like those most people face every day. They also plan to look at PFAS levels and clinical outcomes in patients with colorectal cancer.

“Many in vitro studies can’t be translated into humans,” Johnson said, “but I think understanding first the mechanisms of how they can actually affect cancer cell growth is important.”

Source: Yale University

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[cmipooja]

Global Colonoscopy Devices Market Is Estimated To Witness High Growth Owing To Increasing Adoption of Minimally Invasive Procedures

The global Colonoscopy Devices Market is estimated to be valued at US$2,375.9 million in 2022 and is expected to exhibit a CAGR of 5.2% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: Colonoscopy devices are used for the diagnosis and treatment of various gastrointestinal disorders. These devices allow physicians to examine the inner lining of the colon and rectum. The advantages of using colonoscopy devices include early detection of colorectal cancer, removal of polyps, and diagnosis of various gastrointestinal conditions. The increasing prevalence of colorectal cancer and gastrointestinal disorders is driving the demand for colonoscopy devices. The need for accurate and early diagnosis is also fueling market growth. Market Key Trends: One key trend in the global colonoscopy devices market is the increasing adoption of minimally invasive procedures. Minimally invasive procedures offer several advantages over traditional open surgeries, such as reduced pain, shorter recovery time, and minimal scarring. This trend is driven by the growing patient preference for less invasive treatments and advancements in technology that support minimally invasive procedures. For example, the development of advanced imaging systems and robotic-assisted surgeries has led to more precise and efficient colonoscopies. PEST Analysis: - Political: Government initiatives and policies promoting colorectal cancer screening programs drive market growth. - Economic: Increasing healthcare expenditure and insurance coverage for colonoscopy procedures contribute to market expansion. - Social: Growing awareness about the importance of early detection and prevention of colorectal cancer boosts market demand. - Technological: Advancements in imaging technology and robotic-assisted surgeries have improved the accuracy and efficiency of colonoscopies. Key Takeaways: 1: The Global Colonoscopy Devices Market Size is expected to witness high growth, exhibiting a CAGR of 5.2% over the forecast period, due to increasing adoption of minimally invasive procedures. Minimally invasive procedures offer advantages such as reduced pain and faster recovery, driving market demand. 2: In terms of regional analysis, North America is the fastest-growing and dominating region in the global colonoscopy devices market. This can be attributed to the high prevalence of colorectal cancer, well-established healthcare infrastructure, and favorable reimbursement policies. Europe is also a significant market, supported by increasing awareness and government initiatives for colorectal cancer screening. 3: Key players operating in the global colonoscopy devices market include Karl Storz SE & Co. KG, Olympus Corporation, Endo Med Systems GmbH, HOYA Corporation, Getinge AB, Avantis Medical Systems, Boston Scientific Corporation, and FUJIFILM Holdings Corporation. These companies focus on product innovations, strategic collaborations, and mergers and acquisitions to enhance their market presence. In conclusion, the global colonoscopy devices market is poised for significant growth due to the increasing adoption of minimally invasive procedures. Factors such as the rising prevalence of colorectal cancer and gastrointestinal disorders, along with technological advancements, are driving market demand. North America and Europe are the key regions driving market growth. Key players in the market continue to innovate and collaborate to expand their product portfolios and gain a competitive edge.

[munaeem]

What are the treatment options for colorectal cancer?

Treatment options for colorectal cancer depend on the stage and extent of the disease. The most common treatment for colorectal cancer is surgery, which may involve removing tumors, removing the affected section of the colon, reattaching healthy ends of the intestines, and removing nearby lymph nodes. In rare cases, the entire colon may need to be removed[1][2]. Patients may receive chemotherapy…

[reportwire]

Kirstie Alley died of colon cancer. Here's how to lower your risk | CNN

Kirstie Alley died of colon cancer. Here’s how to lower your risk | CNN

CNN  —  Colon cancer has claimed another life. Emmy Award and Golden Globe winner Kirstie Alley, best known for her roles in the television sitcoms “Cheers” and “Veronica’s Closet,” died Monday at age 71 after battling cancer that was “recently discovered,” according to a family statement. A representative for Alley confirmed to CNN via email on Tuesday that she had been diagnosed with colon…

[daniellalloyd]

Expert Colorectal Surgeons Triumph in Pilonidal Cyst Operations

We're thrilled to announce a groundbreaking achievement in medical care! Expert colorectal surgeons have achieved remarkable success in pilonidal cyst operations, showcasing their unparalleled expertise and dedication to patient well-being.

Their recent triumph in pilonidal cyst surgeries marks a significant milestone in healthcare, highlighting the importance of specialized skills and cutting-edge techniques in addressing complex medical conditions.

Learn more about the article and explore the services  pilonidal cyst surgeries